In River City, where magic used to thrive and is now fading, the witches who once ruled the city along with their powerful King have become all but obsolete. The city's crumbling government is now controlled primarily by the new university and teaching hospital, which has grown to take over half of the city.

Moving between the decaying Old City and the ruthless New, four young queer people struggle with the daily hazards of life—work, school, dodging ruthless cops and unscrupulous scientists—not realizing that they have been selected to play in an age-old drama that revives the flow of magic through their world. When a mysterious death rocks their fragile peace, the four are brought into each other's orbits as they uncover a deeper magical conspiracy.

We All Fall Down examines the complex network of pain created by power differentials, even between people who love each other—and how it is possible to be queer and turn out just fine.